Schistosoma mansoni in IL-4-deficient mice
نویسندگان
چکیده
منابع مشابه
Concomitant immunity to Schistosoma mansoni in mice.
OBJECTIVE The aim of the present study was to confirm observations on the concomitant immunity to Schistosoma mansoni in mice and assess its effects on the resistance of mice to a challenge infection. METHODS Cercariae from infected Biomphalaria glabrata were used to infect mice. Twenty mice were infected with a single dose of S. mansoni cercariae. The animals were randomly divided into two g...
متن کاملHybridization of Schistosoma mansoni and Schistosoma japonicum in mice.
Crossing experiments in mice with two human species of Schistosoma japonicum (Taiwan strain) and Schistosoma mansoni (Puerto Rican strain) were performed. The hybrid miracidia from the cross between female S. japonicum and male S. mansoni infected both Biophalaria glabrata and Oncomalania h. chiui. However, those from the reciprocal crossing could infect only B. glabrata. B. glabrata infected w...
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The initial immune response to Schistosoma mansoni eggs presumably results in IL-4 production, as schistosome eggs are strong Th2-inducing antigens and the differentiation of antigen-specific Th2 cells is largely dependent on the presence of IL-4 during priming of naive Th cells. Consistent with this concept, intraperitoneal injection of mice with schistosome eggs results in an upregulation of ...
متن کاملEnhanced cytotoxic T cell activity in IL-4-deficient mice.
CD8+ effectors are critical components of type 1 responses against viral infections as well as for antiviral vaccines. IL-4 plays a clear role as an inhibitor of CD4+ Th1 cells; however, its role in CD8+ T cell regulation appears to be more complex. Thus, IL-4 may augment CD8+ T cell growth, but also limit effector function. Moreover, abundant IL-4 is inhibitory for viral clearance, but the lac...
متن کاملExperimental autoimmune encephalomyelitis in IL-4-deficient mice.
Experimental autoimmune encephalomyelitis (EAE) in an inflammatory demyelinating disease which usually follows a monophasic course. Autoreactive Th1 CD4+ T cells are responsible for the lesions, whereas autoreactive Th2 CD4+ T cells can, upon adoptive transfer, suppress the disease process. However, the role of IL-4 and Th2 cells in the spontaneous remission of EAE and in the prevention of rela...
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ژورنال
عنوان ژورنال: International Immunology
سال: 1996
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/8.4.435